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New Endoscopic Therapy for Type 2 Diabetes and Obesity

Breakthrough Therapy for Type 2 Diabetes and Obesity to be Highlighted at DDW

By Alex Escalona, MD

Type 2 diabetes and obesity are chronic diseases of growing proportions in Chile, as they are in the rest of the world. The most recent estimates from the International Diabetes Federation (IDF) indicate that type 2 diabetes affects approximately 320 million people worldwide and that 90% of these cases are caused by excess weight. Drug therapy can work well in some patients; however, it often becomes less effective over time and can lead to weight gain. Bariatric surgery can also be an effective option; however, it has serious safety and side effect risks, requires permanent changes to the anatomy and several weeks of recovery time.

In my practice, we are using a new, non-surgical approach called EndoBarrier® Therapy, to treat patients who have type 2 diabetes and are obese. EndoBarrier is a breakthrough, endoscopically-placed device that has been studied in 13 clinical trials with over 500 patients. It has been shown to achieve target HbA1c levels in 80% of patients, achieve weight loss of more than 20%, and improve important metabolic functions including cholesterol, blood sugar and triglycerides within a year.1 EndoBarrier is a thin, flexible, tube-shaped liner that works by creating a physical barrier between food and a portion of the intestinal wall. Food bypasses the duodenum and proximal jejunum which affects certain gastrointestinal hormones involved in insulin sensitivity, glucose metabolism and satiety.

With EndoBarrier Therapy, my patients report increased energy, feeling full for a longer period of time after eating, and immediate and continued weight loss.  We have found that EndoBarrier Therapy has a rapid and sustained effect that enables patients to have a reduced reliance on diabetes medications, including insulin. In my practice, I use EndoBarrier Therapy for those patients whose type 2 diabetes and obesity can’t be well controlled with current medications or lifestyle changes. Patients tell us that they really like EndoBarrier Therapy because it is a simple procedure that is reversible; and they see improvements right away. They are also able to avoid long-term side effects such as anemia and nutritional deficiency that can be seen in patients who opt for a permanent surgical solution.

At this year’s DDW, I have the opportunity to demonstrate what EndoBarrier Therapy is and how it works during the workshop “Xtreme Endoscopic Toolbox: New and Cutting Edge Therapies” on Sunday, May 20, 7:30–10 a.m. This workshop will feature several of my esteemed colleagues and will be a hands-on presentation and interactive session to discuss emerging technologies currently in use worldwide for the endoscopic treatment of obesity.

If you are interested in new technologies and devices to help your patients who are struggling with type 2 diabetes and obesity, then please join us for this workshop.

Watch Dr. Escalona describe his presentation in English or Spanish:


[1] C de Jonge, JW Greve, N Bouvy, et al, EndoBarrier Gastrointestinal Liner treatment rapidly improves diabetes parameters paralleled by increased postprandial GLP-1 and PYY levels in obese type 2 diabetic patients, Department of Surgery, Maastricht University Medical Centre, presented at IFSO 2011, Hamburg, Germany.

Alex Escalona, MD is Assistant Professor of Surgery, Department of Digestive Surgery, Pontificia Universidad Católica de Chile, Santiago, Chile


  1. I have read the trials about endobarrier and I work in a bariatric team in Venezuela. I am attending DDW in San Diego and would like to know if that workshop has a price and where will it be. I am very interested in this workshop

    • Hi there – This presentation is part of the ASGE Hands-On Workshop, Xtreme Endoscopic Toolbox: New and Cutting Edge Therapies. It takes place on Sunday, May 20, 7:30-10 a.m. The room number is Hall H.

      There is an additional fee to attend this workshop, and the price depends on whether you are an ASGE member. The prices are: ASGE Member: $375, Nonmember: $425, ASGE Member Trainee: $225.

      You can find more information about this session in MyDDW ( If you decide that you want to attend, you can add this session to your DDW registration by logging in to the Registration Resource Center (

  2. Thanks Cristina for your interest in our work and this workshop. I hope to see you there. Let us know if you have more questions.

    • Dear Dr Escalona,
      Is there space still available in your workshop?


      • Yes! Register for it in Hall D Lobby of the San Diego Convention Center. Registration is open noon-8 p.m. today, and 7 a.m.-6 p.m. Saturday. The workshop is Sunday morning, so you’ll want to register today or tomorrow.

  3. me parece maravilloso el estudio y sus resultados, pero tengo una gran pregunta, un diabetico tipo 1 insulino dependiente…puede operarse?

    gracias por su respuesta.

  4. do you only get diabetes symptoms when your glucose is high?

  5. All forms of diabetes have been treatable since insulin became available in 1921, and type 2 diabetes may be controlled with medications. Insulin and some oral medications can cause hypoglycemia (low blood sugars), which can be dangerous if severe. Both types 1 and 2 are chronic conditions that cannot be cured. Pancreas transplants have been tried with limited success in type 1 DM; gastric bypass surgery has been successful in many with morbid obesity and type 2 DM. Gestational diabetes usually resolves after delivery.^.

    Head to our blog site as well

  6. Diabetes, often referred to by doctors as diabetes mellitus, describes a group of metabolic diseases in which the person has high blood glucose (blood sugar), either because insulin production is inadequate, or because the body’s cells do not respond properly to insulin, or both. Patients with high blood sugar will typically experience polyuria (frequent urination), they will become increasingly thirsty (polydipsia) and hungry (polyphagia).`:;”

    Have a look at our very own online site too http://calaguastourpackage.comds Lisandra Vanecek

  7. Being extremely obese means you are especially likely to have health problems related to your weight. The good news is that even modest weight loss can improve or prevent the health problems associated with obesity. You can usually lose weight through dietary changes, increased physical activity and behavior changes. In some cases, prescription medications or weight-loss surgery may be options. ….“

    My own blog <

  8. Dr. Escalona, le comento que soy una paciente de Punta Arenas a la cual hace 12 años app el Dr. Sergio Guzman le practico un Bypas gastrico, al poco tiempo se me ditalo excesivamente la uniòn del estomago con el intestino, segun la última esdoscopia, esta expandida a 30 milimetros, por lo cual el efecxto del Bypass se perdio y he recuperado peso, estoy en 120 kilos app.- Por internet me entere de un procedimiento llamado Gastroplastia Endoscopica para suturar por via esdoscopia la uniòn entre el estomago e intestino.- Necesito evaluaciòn y si fuera posible le enviaria todos los exmanes actualkizados para concertar fecha para el procedimiento y asi no tener que viajar tantas veces a Santiago.- Mi celular es 77537087 para ver si su secretaria pudiera darme hora mèdica.- Desde ya agradecida.-

  9. Greetings! This is my first visit to your blog! We are a team of volunteers and starting a new initiative in a community in the
    same niche. Your blog provided us useful information to work on.
    You have done a wonderful job!

  10. Ԝell I really liked studying it. This subject procurd by you is very constructive fߋr proper plɑnning.


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